Thy1 fibroblast

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August undefined, 2024

Webb6 feb. 2024 · By using either sorted or transfected lung fibroblasts, ... Thy-1 deficient (Thy1−/−) mice displayed persistence of myofibroblasts in the resolution phase of bleomycin-induced fibrosis, ... WebbTaken together, our studies identify cardiac myofibroblasts lacking Thy1 as a pathogenic CF fraction in cardiac fibrosis and suggest important roles of Thy1 in pathophysiology of …

Portal fibroblasts marked by the surface antigen Thy1 ... - PubMed

Webb22 mars 2024 · Conclusion: This study establishes Thy1 as a useful cell surface marker to prospectively identify and isolate periportal fibroblasts and further highlights a … Webb1 sep. 2024 · Thy1 + activated PFs accounted for 26%, 51%, and 54% of collagen-GFP + myofibroblasts in Mdr2−/− mice at 4, 8, and 16 weeks of age, respectively. The remaining collagen-GFP + myofibroblasts were composed of activated HSCs, suggesting that PFs and HSCs are both activated in Mdr2−/− mice. self report studies crime uk

Evidence for Enhanced Thy-1 (CD90) Expression in Orbital …

Webb5 maj 2024 · Multi-omics analysis of fibroblasts isolated from aged and young mice revealed that fibroblasts from aged mice exhibit secretory inflammatory phenotypes. 101 These activated fibroblasts are marked by the higher expression of THY1 and PDGFRα, and secrete several inflammatory cytokines, such as IL-1β, IL-6, and TNF. Webb23 aug. 2024 · Croft, A. P. et al. Distinct fibroblast subsets drive inflammation and damage in arthritis. Nature 570, 246–251 (2024). This article shows that lining-layer THY1– … WebbThy-1+ extraocular muscle–derived fibroblasts were incapable of adipocyte differentiation, while approximately 50% of fibroblasts from the connective/adipose tissue depot … self report techniques psychology

CD34+THY1+ synovial fibroblast subset in arthritic joints …

Thy-1 expression in human fibroblast subsets defines ... - PubMed

WebbThy-1 expression in human fibroblast subsets defines myofibroblastic or lipofibroblastic phenotypes. Fibroblasts represent a dynamic population of cells, exhibiting functional … Webb21 okt. 2024 · THY1 (CD90) was highly expressed in pericytes and inflammatory fibroblasts, but at lower levels in ABCA8 + fibroblasts (Fig. 4c ). Fig. 4: Stromal architecture of the large and small... self report psychology test self report psychology example

"Webb29 juli 2014 · Thus, the major sources of myofibroblasts in liver fibrosis are the endogenous liver mesenchymal cells, which consist of portal fibroblasts and hepatic stellate cells. Quiescent hepatic stellate cells (qHSCs) are located in the space of Disse, store retinoids in lipid droplets, and express neural markers, such as glial fibrillary acidic … " - Thy1 fibroblast

Thy1 fibroblast

Evidence for Enhanced Thy-1 (CD90) Expression in Orbital …

Webb20 apr. 2024 · The cells were grouped into three major subsets — CD34 − THY1 −, CD34 − THY1 + and CD34 + fibroblasts — using principal component analysis (PCA) of the … Webb1 jan. 2016 · Remarkably, the majority of the fibroblast pool from the adipose/connective orbital tissue consists of Thy1 + fibroblasts, while ∼30–40% of the fibroblasts are Thy1 −. In contrast, fibroblasts from the extra-ocular muscles uniformly express Thy1 (Smith et al., 2002). So far there is no clear explanation what controls this heterogeneity.

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WebbBackground: Thy-1 is a surface protein that defines functionally distinct subpopulations of fibroblasts, with those lacking the antigen being capable of adipogenesis. Because increased fat cell development is a hallmark of the orbit in Graves' ophthalmopathy (GO), we wished to compare baseline Thy-1 expression in orbital fibroblasts from GO patients … Webb23 feb. 2024 · Low expression of TNFRSF11B in CD34 – THY1 – fibroblasts and CD34 – THY1 + fibroblasts was confirmed by direct protein measurement from supernatant of …

Webb1 jan. 2010 · Thy1 expression is induced in Thy1 (-) fibroblasts by treatment with 5-aza-2-deoxycytidine, a DNA methyltransferase inhibitor. Suppression of THY1 transcription via … Webb15 nov. 2006 · Normal fibroblast subpopulations have differential surface expression of the GPI-linked raft protein Thy-1, which correlates with differences in cellular adhesion and migration in vitro. Thrombospondin-1 (TSP-1) induces an intermediate state of adhesion in fibroblasts and other cells which facilitat …

Webb15 feb. 2024 · Synovial fibroblasts (SFs) in rheumatoid arthritis (RA) and osteoarthritis (OA) play biphasic roles in joint destruction and regeneration of bone/cartilage as … Webb27 juni 2024 · Buckley and colleagues found that thymus cell antigen 1 (THY1) expression could distinguish between FAPα-expressing fibroblasts in the synovial sub-lining (FAPα …

Webb1 sep. 2024 · Thy1 has also been used as a marker to identify subpopulations of FBs [18]. Interestingly, previous studies have identified that Thy1 positive (Thy1+) and Thy1 negative (Thy1-) FBs derived from lung tissues have distinct functions [19,20], such as proliferation [21], differentiation to myofibroblast, and correlation with fibrosis [15,22].

Webb1 jan. 2010 · Thy1 expression is induced in Thy1 (-) fibroblasts by treatment with 5-aza-2-deoxycytidine, a DNA methyltransferase inhibitor. Suppression of THY1 transcription via hypermethylation of its promoter in THY1 (-) lung fibroblasts has implications in the disease idiopathic pulmonary fibrosis (IPF). self report traffic crashWebbFibroblasts consist of heterogeneous subpopulations that have distinct roles in fibrotic responses. Previously we reported enhanced proliferation in response to fibrogenic … self reported academic record srarWebb25 juli 2024 · Because Thy-1 (CD90) marks CAFs that promote tumor cell invasion in a murine model of Kras G12D -driven lung adenocarcinoma (Kras LA1 ), here we postulated that human lung adenocarcinomas containing Thy-1 + CAFs have a worse prognosis. We first examined the location of Thy-1 + CAFs within human lung adenocarcinomas. self reported academic record website