Webb25 aug. 2024 · Shank3 Overexpression Induces Autophagy In the hypoxia group, western blot analysis showed significantly increased Shank3, Atg7, Beclin1, and LC3-II protein levels as compared with the control group ( Figures 4A–F ). Meanwhile, the p62 expression of MI + Tg-Shank3 was lower than the control group ( Figures 4A–C ). FIGURE 4 Figure 4. WebbShank3 overexpression in rat cerebellar granule cells induces dendritic spine and synapse formation, whereas Shank3 knockdown in hippocampal neurons reduces the number of dendritic spines (1). Both Shank1 and Shank3 may form structural frameworks in the PSD via different molecular mechanisms (18, 19).
Full article: Transcriptome analyses suggest minimal effects of …
WebbSHANK3 is a scaffolding protein that is enriched in postsynaptic densities of excitatory synapses but ubiquitously expressed in most cells. SHANK3 gene mutations are significantly associated with autism spectrum disorders (ASDs), and deletion of SHANK3 is thought to cause the major symptoms of Phelan-McDermid syndrome. Webb11 apr. 2024 · Loss of Predominant Shank3 Isoforms Results in Hippocampus-Dependent Impairments in Behavior and Syn... Cognitive Decline Typical of Frontotemporal Lobar Degeneration in Transgenic Mice Expressing the 25-... Synaptic activity in X-linked mental retardation: a thorny issue blue cross anthem texas
SHANK3 overexpression causes manic-like behavior with unique ...
Webb28 juni 2024 · Furthermore, we could co-immunoprecipitate Shank3, Rhes and Wiskott-Aldrich syndrome protein family verprolin-homologous protein 1 (WAVE1) proteins from the striatal lysate of Shank3 TG mice. By comparing with the gene sets of psychiatric disorders, we also observed that the 94 proteins of Shank3-mTORC1 interactome were … Webb29 maj 2024 · Consequently, SHANK3 overexpression induced a decrease in the number of filopodia spines on hippocampal neurons , and SHANK3-knockdown induced longer … WebbHowever, SHANK3 overexpression per se has not been established as a cause of human disorders because 22q13 duplications involve several genes. Here we report that Shank3 … blue cross anthem precert