Web目的确定产前束缚应激刺激对子代大鼠脑海马中Bax、Bcl-2、Fas和FasL表达的影响.方法在母鼠怀孕的13～19 d,每天进行3次束缚应激,每次45 min.于雌、雄仔鼠1月龄时对脑组织切片应用免疫组化方法检测海马中Bax、Bcl-2、Fas和FasL的表达.结果应激组Bax的表达强于对照组(P＜0.05),Bcl-2的表达弱于对照组(P＜0.05),Fas ... WebFas ligand or FasL (CD178 or CD95L) is a homotrimeric human type II transmembrane protein. The Fas ligand gene (FASLG) on chromosome 1q24.3 encodes the Fas ligand …

An Inhibitor of Fas Ligand-induced Apoptosis: R&D Systems

WebOct 1, 2009 · FasL function is regulated by deposition in the plasma membrane and metalloprotease-mediated shedding, but it is unclear what the respective roles of these secreted and membrane-bound forms are ... WebApr 12, 2024 · Long-term exposure to environmental pollutants combined with frailty and a decline of immune function makes the elderly population particularly susceptible to T2D. 18 Cohort studies ... (MIEs): activation of first apoptosis signal ligand (FasL) and protease-activated receptor (PAR), as well as inhibition of tumor necrosis factor (TNF), TNF ... farmstyle couches

Age-Dependent Changes in FasL (CD95L) Modulate Macrophage Function …

WebMar 1, 2000 · Whether down-modulation of FasL expression and function is a primary event or is secondary to the changes taking place at the time of parturition awaits more precise characterization. WebOct 1, 2009 · Fas ligand (FasL), an apoptosis-inducing member of the TNF cytokine family, and its receptor Fas are critical for the shutdown of chronic immune responses and prevention of autoimmunity. Accordingly, mutations in their genes cause severe lymphadenopathy and autoimmune disease in mice and humans. WebJul 1, 2001 · One last issue that is often raised in challenge to the idea that FasL functions in immune privilege are the well known difficulties in the use of some antibodies to detect FasL, especially in ... farmstyle comfy couch